In an LC-MS/MS study of the proteome of pancreatic ductal fluid from patients with PC, pancreatitis, or IPMN and healthy controls [105], higher concentrations of pancreatic amylase (AMYP), PRSS1, glycoprotein GP2-1, coiled-coil domain-containing protein 132 (CCDC132), REG-1-Alpha, REG-1-Beta, and REG-3-Alpha, and lower concentrations of pancreatic lipase-related protein (LIPRP) 2 were observed in samples from patients with cancer than in those from healthy individuals. The gene discussed is VPS50; the disease is pachyonychia congenita.