Phase III trial PA.3 recently reported that several plasma protein-based biomarkers were associated with tumor stage and survival in PC; thus, interleukin (IL)-6, IL-8, carcinoembryonic antigen (CEA), and hypoxia-inducible factor 1-alpha (HIF-1α) levels were related to the prognosis, while increased IL-8, CEA, platelet-derived growth factor receptor alpha (PDFGFRα), and mucin (MUC)-1 concentrations were related to metastasization. This evidence concerns the gene HIF1A and pachyonychia congenita.