A study of urinary proteomes in samples from patients with PC or chronic pancreatitis and healthy controls selected the following biomarkers as candidates for the detection of early-stage PC: lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), regenerating gene (REG)-1-alpha, and trefoil factor (TFF)-1. The gene discussed is TFF1; the disease is pachyonychia congenita.