TNFRSF8 and infection: Epstein Barr Virus (EBV), which is believed as a key component in the etiology of ENKTL, induce the CD30 expression by infection and transformation of lymphocytes, because EBV integration site (EBVS1) has been demonstrated close to the CD30 locus (at 1p35) of human which may activate the CD30 expression [15].