Former research has demonstrated that CD30 expresses from non-neoplastic lymphoid tissue (some activated T and B immunoblasts) to classical Hodgkin lymphoma (cHL) and anaplastic large cell lymphoma (ALCL) [5, 9]; it has also been reported that CD30 expresses in 20% to 50%, even 70% patients with ENKTL [6]. Here, TNFRSF8 is linked to classic Hodgkin lymphoma.