In addition to the essential role of VEGF also other growth factors were identified to play an important role in GBM angiogenesis such as hepatocyte growth factor (HGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), or angiopoietins and interleukin-8 [55–58]. This evidence concerns the gene CXCL8 and glioblastoma.