Based on the above evidence, we evaluated the intratumoral expression of ERCC1, RRM1, RRM2, hENT1, dCK, cN-II and CDA (Figure 1) by validated quantitative-PCR methods in two cohort of NSCLC patients treated with platinum/gemcitabine-based regimens and we correlated gene expression levels with response to treatment and outcome. The gene discussed is RRM2; the disease is non-small cell lung carcinoma.