Among these, four proteins showed a downregulation specifically observed in the most aggressive M5-T1 tumor: RT1 class I histocompatibility antigen, AA alpha chain (HA12) (Günther et al. 2001), GTPase IMAP family member 4 (encoded by Gimap4), antigen peptide transporter 2 (encoded by Tap2), and high-affinity immunoglobulin epsilon receptor subunit gamma (encoded by Fcer1g) (Figure 6, top and 2nd rows). The gene discussed is TAP2; the disease is neoplasm.