CTRB1 and colorectal cancer: Interestingly, another specificity of the M5-T1 tumor was an increased abundance of other proteins involved in the reorganization of the ECM, such as: chymotrypsinogen B and trypsins, which have been found to be elevated in tissue interstitial fluids of colorectal cancer [66]; fibromodulin, which was revealed as an important regulator of glioma cell migration [67]; and extracellular matrix protein 1, for which overexpression is related to a very poor diagnosis in various cancers [68, 69].