In the case of progressive CLL, 27 CD antigens including SLAMF5, are differentially abundant (CD11a, CD11b, CD11c, CD18, CD19, CD20, CD21, CD22, CD23, CD24, CD25, CD38, CD40, CD43, CD45, CD45RA, CD52, CD69, CD81, CD98, CD102, CD148, CD180, CD196 and CD270). The gene discussed is CD38; the disease is B-cell chronic lymphocytic leukemia.