Furthermore, mice injected with the moderately metastatic sub-line MDA-231-BT1 overexpressing IKKβ experienced severe cachexia (Figure 3C, 40% increase after 55 days, p < 0.05) and became morbid and were sacrificed before 55 days compared to only 50% from the mock control group (p < 0.05) (Figure 3D). The gene discussed is IKBKB; the disease is Cachexia.