A retrospective analysis of a cohort of patients with metastatic breast cancer [23] revealed that mRNA expression of IKKβ is elevated in primary breast carcinoma (Figure 1A, p = 0.00032, n = 185) and it is strongly associated with disease recurrence (Figure 1B, left panel, p = 0.0001, n = 560) and bone metastasis relapse (Figure 1B, right panel, p = 0.03, n = 560). Here, IKBKB is linked to bone metastasis.