Our present work assessed the potency of AZ628 versus Dabrafenib in combination with Trametinib as measured by cell viability, caspase 3/7 activation, and ERK pathway activation in a tumor derived cell line harboring an impaired kinase mutation (H1666 cell line) both short term (24–48h) and long term (1 week). This evidence concerns the gene CASP3 and neoplasm.