Moreover, the phosphatidylinositol-4,5-bisphosphate 3- kinase, catalytic subunit alpha (PIK3CA) oncogene was found to be mutated in 8/28 (29%) penile cancer cases by Andersson et al. [19] and Ferrandiz-Pulido et al. [20] more recently found a lower prevalence of PIK3CA mutations in 6/65 (9%) PSCC cases. This evidence concerns the gene PIK3CA and squamous cell carcinoma of penis.