Given the fact that SOCE is involved in cancer cell proliferation and that RTKs might be, at least in some circumstances, linked to Ca2+ signalling, we have evaluated the effects of tyrosine kinase inhibitors (TKIs) or monoclonal antibodies targeting RTKs in the regulation of SOCE in ErbB2-overpressing breast cancer cell line. This evidence concerns the gene ERBB2 and breast carcinoma.