SOCS3 and urinary bladder carcinoma: Gaballah et al. [16] detected SOCS3 expression in highly malignant bladder cancer, low-grade bladder cancer, and normal bladder tissue using RT-PCR and found that SOCS3 expression was significantly lower in highly malignant bladder cancer than in low-grade bladder cancer and normal bladder tissue, suggesting that decreased SOCS3 expression might be associated with the development of bladder cancer.