To understand the mechanism by which Uev1A promotes metastasis in colon cancer cells, we took into account that Uev1A has been reported to activate NF-κB in HepG2 cells [23], and that, once released into the nucleus, NF-κB regulates the expression of a large number of genes critical for tumorigenesis, inflammation and metastasis [21]. Here, UBE2V1 is linked to malignant colon neoplasm.