Mice with homozygous deletions of either BRCA1 or BRCA2 display higher levels of cellular senescence and apoptosis and are embryonically lethal [9–10], additionally BRCA1+/− p53+/− mice displayed multiple premature aging phenotypes, such as osteoporosis, atrophy, kyphosis, decreased body weight, and increased tumor incidence [11]. The gene discussed is BRCA1; the disease is osteoporosis.