KDM5C and Intellectual disability: For example, in mice, the X-linked gene kdm5c plays a crucial role in brain development (Berletch et al., 2011) and in humans, KDM5C mutations can result in neurodevelopmental abnormalities such as autism, intellectual disability and excessive aggression in males (Goncalves et al., 2014; Brookes et al., 2015; Iwase et al., 2016).