Furthermore, three TFs highly expressed in multiple myeloma and pivotal regulators of malignancy-specific gene expression, the Ikaros family zinc finger protein-1 and -3 (IKZF1 and IKZF3) and IRF4, are potent repressors of MICA expression in this hematological cancer (30, 31). Here, IKZF1 is linked to plasma cell myeloma.