A cogent example is the TF STAT3 shown to directly interact with MICA promoter and repress its transcription in colon cancer cells (28); the same mechanism was found to occur also in multiple myeloma cells where the serine–threonine kinase GSK3 was identified as an important upstream regulator of STAT3 contributing to the inhibition of MICA expression (29). The gene discussed is STAT3; the disease is malignant colon neoplasm.