In fact, it has been observed that the KiSS-1 transcriptional activity is present in node-negative breast cancer patients, primary breast cancer, and metastatic deposits, but higher expression, due to the molecular alteration, occurs essentially in localized tumors with no nodal involvement, thus confirming that restoring the function of the KiSS-1 gene could be a promising approach to stop micrometastatic growth and prevent metastatic diffusion in distant sites (20). Here, KISS1 is linked to breast cancer.