The nuclear receptor corepressors (N-CoR)/Histone Deacetylase 3 (HDAC3) complex is necessary for repression by Rev-erbα, with liver-specific HDAC3 knockout causing deregulated lipid metabolism and hepatic steatosis in the mouse (Feng et al., 2011). The gene discussed is HDAC3; the disease is Hepatic steatosis.