Conversely, time-restricted feeding of a high-fat diet for 8 h during nighttime induces mice to eat equivalent calories, in respect to controls with ad libitum access to food, but the former show enhanced CREB, mTOR, and AMPK pathway signaling, increased oscillations of core and clock controlled genes, and do not develop obesity, hyperinsulinemia, hepatic steatosis, and inflammation, whilst also showing superior motor coordination (Hatori et al., 2012; Chaix et al., 2014). The gene discussed is CLOCK; the disease is obesity due to melanocortin 4 receptor deficiency.