Accordingly, whole body Arntl−/− mice show glucose intolerance, hypoinsulinemia, an increased respiratory quotient, reduced fat storage, increased circulating fatty acids, increased ectopic fat formation in liver and muscle, and hypoinsulinemia, whilst mouse liver specific Arntl knock-out induces hypoglycemia in the resting state (Lamia et al., 2008; Marcheva et al., 2010; Shimba et al., 2011). The gene discussed is BMAL1; the disease is Glucose intolerance.