Whole-body double knockout Rev-erbα and Rev-erbβ mice show a phenotype characterized by altered rhythmic expression of the core clock and lipid homeostatic gene networks leading to altered circadian wheel-running behavior, hyperglycemia, hyperlipidemia and hepatic steatosis (Bugge et al., 2012; Cho et al., 2012). Here, CLOCK is linked to hyperlipidemia.