TNF and metabolic dysfunction-associated steatohepatitis: The loss of these inflammasomes and their products induces changes of the distribution of gut microbiota biogeography as well as the levels of influx of TLR4 and TLR9 agonists into the portal circulation, with the concurrent increase in hepatic tumor-necrosis factor (TNF)-α expression driving NASH progression (Henao-Mejia et al., 2012).