The multifaceted interaction among the metabolic pathways involved in bile acids, glucose, and lipids turnover as well as cellular processes comprising autophagy, inflammation and their regulation by the biological clock in response to nutrients, bile acids, hormones, nuclear receptors, or gut microbiota is central in the regulation of metabolism and in the manifestation of hepatic steatosis (Table 1). The gene discussed is CLOCK; the disease is Hepatic steatosis.