LIAS and infection: Thus, the 10-1074-LS bNAb conferred a 2.2-fold increase (12.5 to 27) in the number of challenges needed to establish an infection compared with the unmodified 10-1074 monoclonal antibody, whereas the 3BNC117-LS bNAb conferred a modest 1.3-fold (13 to 17 challenges) improvement.