As an interaction pair in colorectal cancer pathway and Wnt signalling pathway, genomic alterations in the pair of APC and β-catenin (CTNNB1) significantly associate with reductions in DFS (disease-free survival) in patients with prostate cancer, It’s interesting that mutations in APC are mutually exclusive from those occurring in β-catenin in both colon cancer and prostate cancer40,41. Here, CTNNB1 is linked to Familial prostate cancer.