ENPP1 and Generalized arterial calcification of infancy: ABCC6 mutations are also linked to some cases of Generalized Arterial Calcification of Infancy (GACI; OMIM #614473)25, a calcification disorder that affects the circulatory system26 and is associated with mutations of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) gene27.