ABCC6 mutations are also linked to some cases of Generalized Arterial Calcification of Infancy (GACI; OMIM #614473)25, a calcification disorder that affects the circulatory system26 and is associated with mutations of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) gene27. This evidence concerns the gene ENPP1 and arterial calcification, generalized, of infancy, 1.