IDH1 and neoplasm: IDH305 potently reduces the 2HG production in preclinical models, in which a single dose of 100 mg/kg is sufficient to reduce the tumor 2HG levels by 95% in nude mice with IDH1 mutant flank tumors, and has shown in vitro antiproliferative effects (Novartis Pharmaceuticals Phase I clinical trial protocol, ClinicalTrials.gov identifier: NCT02381886).