SOAT1 and viral infectious disease: In this review, several topics are discussed: the discovery of the JAK/STAT pathway, including the canonical JAK/STAT pathway activated by IFNs, tyrosine phosphorylation-independent non-canonical STAT activation, virus-induced serine monophosphorylation of STATs, as well as the role of monophosphorylation of STATs during inflammation triggered by viral infection.