When we evaluated protein expression on cancer tissues, the data confirmed the same trend (Cuzick z = +3.05, p = 0.002 for IGF1R and z = −3.60, p = 3 × 10−4 for phospho-protein) and also showed an increased expression of total ERK1/2 (Cuzick z = +3.04, p = 0.002) across the groups. The gene discussed is MAPK3; the disease is cancer.