In an azoxymethane/dextran sodium sulphate (AOM/DSS) colitis‐associated colon cancer model, TPL2 deficiency increases the development of tumours in mice compared to WT mice, whereas in p38γ/δ−/− mice tumour development is decreased (Koliaraki et al, 2012; Del Reino et al, 2014). This evidence concerns the gene MAP3K8 and colitis.