Further investigation of the role of TCF19 in activating apoptotic pathways confirmed that TCF19 levels positively correlated with BRD4 protein levels and sensitivity to BET inhibitors; depletion of TCF19 activated the cleavage of caspase‐7 and PARP, and promoted apoptosis of NRAS‐mutant melanoma cells; while the level of TCF19 inversely associated with patient's survival in the cutaneous melanoma TCGA data. Here, TCF19 is linked to melanoma.