HES1 and ocular cancer: Several other lncRNAs have also been shown to alter the chromatin structure of target genes in trans. These include the human PAUPAR orthologue which can inhibit H3K4 trimethylation of the Hes1 promoter in eye cancer cell lines, as well as lncRNA‐HIT which induces p100/CBP‐mediated changes in histone H3K27ac at bound sequences to regulate genes involved in chondrogenesis (Carlson et al, 2015; Ding et al, 2016).