Mice lacking Gjd2/Cx36 show lowered indices of coordinated beta cell Ca2+ activity and loss of pulsatile insulin secretion both in vitro (Ravier et al. 2005) and in vivo (Head et al. 2012), leading to glucose intolerance despite preserved steady-state insulin release (Ravier et al. 2005, Head et al. 2012). Here, INS is linked to Glucose intolerance.