IDH1 and breast carcinoma: As shown in Fig. 8 and Table 4, low IDH1 expression levels and high snail expression levels were significantly associated with poor survival in patients with breast cancer (CHR for DSS, 2.10; 95% CI, 1.22–3.63; p = 0.008 and CHR for DFS, 2.49; 95% CI, 1.42–4.37, p = 0.001), even after adjustment for clinicopathological factors (AHR for DSS, 2.34; 95% CI, 1.32–4.16; p = 0.004 and AHR for DFS, 2.50; 95% CI, 1.39–4.50; p = 0.002).