We further examined the expression levels of IDH1 in eight breast cancer cell lines, including cells with low invasive ability (MCF7, T47D, SK-BR3, MDA-MB-468, and MDA-MB-453) and cells with high invasion ability (BT549, Hs578T, and MDA-MB-231; Fig. 4a). Here, IDH1 is linked to breast carcinoma.