Adjusted RFS hazard ratios comparing each treatment with A + T were 1.25 (95% CI 0.47–3.35) for A no T, 0.90 (95% CI 0.37–2.20) for AT + HER2, and 1.28 (95% CI 0.55–2.98) for PC (Table 3). The gene discussed is ERBB2; the disease is pachyonychia congenita.