It has been previously shown that the JNK-mediated phosphorylation of AP-1 (c-Jun) upregulates cyclin D1 to drive proliferation in liver cell regeneration and mouse epidermal cell transformation [42, 43], which supported our data that miR-760 inhibited cyclinD1 via AP-1 in CRC cells. Here, CCND1 is linked to colorectal carcinoma.