A recent retrospective review from MD Anderson Cancer Center at a median follow-up of 58 months reported no additional benefit from adjuvant chemotherapy (invasive DFS, RFS, DRFS, and OS) among 894 patients with hormone receptor-positive, HER2-negative, lymph node-negative, early-stage breast cancer with an Oncotype DX Recurrence Score of 11–25 treated at their institution [21]. This evidence concerns the gene NR4A1 and breast cancer.