A paradigm shift in the recommendation for adjuvant chemotherapy was enabled by the advent of the Oncotype DX Recurrence Score (Genomic Health Inc., Redwood City, CA, USA), a 21-gene assay that was validated to predict the rate of distant metastases [5], the risk of breast cancer-related mortality [6], and the benefit of chemotherapy [7] in hormone receptor-positive, node-negative early-stage breast cancer patients treated with endocrine therapy. Here, NR4A1 is linked to breast carcinoma.