We targeted MTH1 in H23 adenocarcinoma (p53-mutated), H522 adenocarcinoma (p53-mutated) and A549 lung carcinoma (wildtype p53) NSCLC cell lines in order to assess if any observed effects are applicable to NSCLC in general and/or are dependent on p53 status, and in MRC-5 normal lung cells to determine if the effects are cancer specific. The gene discussed is TP53; the disease is adenocarcinoma.