Accordingly, the cytotoxicity of TH588 to melanoma cells was recently suggested to correlate to endogenous ROS levels but be independent of MTH1, as TH588 treatment induced melanoma cell death but MTH1 knockdown did not, and TH588-induced apoptosis is not rescued by overexpressing MTH1 or introducing the bacterial homolog of MTH1 that is not inhibited by TH588 [73]. The gene discussed is NUDT1; the disease is melanoma.