CDKN1C and neoplasm: The results of massive RNA-sequencing (RNA-Seq) of the transcript isoforms that encode proteins in the 8 T-LBL samples of the exploratory cohort showed that the mRNA level of CDKN1C was strongly reduced in all analysed tumours compared to that of the normal foetal thymuses, with fold-changes ranging from − 25.99 to − 2.15 in the canonical isoform ENST00000414822.