As in other cancers, the loss of cell cycle control plays a prominent role in the pathogenesis of these malignancies that is primarily attributed to loss of CDKN2A (which encodes the tumour suppressor protein p16INK4A) and, to a lesser extent, loss of RB1 or CDKN1B (which encodes p27/KIP1 protein) and aberrantly high levels of CCND2 (encoding cyclin D2) [2]. The gene discussed is CDKN1B; the disease is cancer.