As in NSCLC cell lines, the level of WT HLTF expression was significantly higher than the level of I21R HLTF expression in tumours of patients with NSCLC (Fig. 3) when considering all patients (median 20.6 vs. 2.2 respectively, Wilcoxon signed-rank test, p = 2.2 × 10− 16). The gene discussed is HLTF; the disease is neoplasm.