EGF and non-small cell lung carcinoma: It has been demonstrated in NSCLC patients treated with Hu-rhEGF-rP64k vaccine in multiple clinical trials, that high anti-EGF antibodies titers followed by the consequent reduction of serum EGF levels correlates with a significant overall survival benefit for subgroups of patients, especially for those patients with high baseline levels of serum EGF [11].