CCN2 and bronchopulmonary dysplasia: Connective tissue growth factor (CTGF), a downstream mediator of transforming growth factor (TGF)‐β, is a matricellular signaling modulator and a key molecule in tissue remodeling.3 As upregulation of CTGF has been detected after mechanical ventilation and hyperoxia in the neonatal lung,4 in proliferating type II lung epithelial cells, and activated fibroblasts of fibrotic lungs,5 it has been suggested that CTGF may contribute to BPD.