MSH6 and neoplasm: We thank the kind support from Professor Rui Henrique (Head of the Department of Pathology of the IPO Porto) for providing information regarding the expression of MSH2 and MSH6 in the tumor tissues of the mutation carriers and from Manuela Pinheiro (postdoc at the Cancer Genetics Group of the CI-IPOP) for providing technical guidance in KASP genotyping.