Considering that most of the genes so far associated with an increased risk for PrCa development have previously been described to predispose to breast/ovarian cancer and/or Lynch syndrome, we looked for missense variants in the 18 genes associated with these diseases, namely ATM, BLM, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, and TP53. Missense variants predicted to be pathogenic by at least 12 of the 15 in silico pathogenicity predictors (including at least three conservation tools) were considered “potentially pathogenic”. The gene discussed is MLH1; the disease is Lynch syndrome.