CHEK2 and pure red-cell aplasia: For the variants found significantly associated (or showing borderline significance) with PrCa development, namely the ATM variant c.8560C>T and the CHEK2 variant c.349A>G, larger cohorts of familial/early-onset PrCa cases would be useful to define cancer risk estimates and the age-standardized PrCa risk attributed to these variants.