This strategy is justifiable by the fact that, with the exception of HOXB13, all the genes so far associated with PrCa hereditary predisposition were previously associated with an increased risk for BrCa, OvCa or other cancers, including those causing the phenotypically heterogeneous diseases hereditary breast/ovarian cancer (HBOC) and Lynch syndrome [20,24,27,50]. This evidence concerns the gene HOXB13 and cancer.