Further studies are required to determine the frequency of germline mutations in these genes in PrCa and other hormone-related cancers, as the pedigrees of both case HPC186 and case HPC447, with the RAD51C and the FANCD2 functionally deleterious mutations, respectively, include relatives affected with BrCa and/or gynecological cancers. The gene discussed is RAD51C; the disease is female reproductive organ cancer.