Using our previously established NGS analysis pipeline [37], and after excluding the few cases in our series with germline mutations in HOXB13 or in genes associated with HBOC or Lynch syndrome [17,27], we found monoallelic truncating/deleterious mutations in seven genes, of which only ATM and CHEK2 have been previously implicated in PrCa development [28–31,34,35,43]. Here, HOXB13 is linked to Lynch syndrome.