There is an auto-regulatory loop for maintenance of EBV latency in NPC cells, in which aberrant NF-κB signaling regulates EBV EBNA1 and BARTs (miR-BARTs and lnc-BARTs) gene expression, while EBNA1 and BARTs in turn keep NF-κB signaling in check for EBV latency program in EBV-infected cells. The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.