However, there are many theories such as (a) chronic hyperglycemia and increased secretion of prostaglandin E2 and tumor necrosis factor alpha (TNF-α) are caused by the accumulation of advanced glycation end products; (b) the presence of oral microbiome in the tissue due to impairment of polymorphonuclear leukocyte function [33,34]; and (c) a change in collagen metabolism due to an increase in collagenase activity and decrease in collagen synthesis [35]. The gene discussed is TNF; the disease is Hyperglycemia.