It is well‐known that Nrf2 protects against the development of emphysema in rodents.6, 7, 8, 9 A recent study demonstrates that Wnt3a stabilizes Nrf2 by preventing its GSK‐3‐dependent phosphorylation and degradation in hepatocytes.10 Furthermore, AMP‐activated protein kinase (AMPK) has been shown to activate Nrf2, which links to GSK‐3β inhibition.11, 12 However, it is unknown whether Nrf2 mediates the protection of Wnt3a and AMPK against pulmonary emphysema. Here, WNT3A is linked to pulmonary emphysema.