14 found that patients with primary ovarian cancer also have an increased risk of second uterine cancer, but Levi showed that patients with ovarian cancer did not have any excess risk of any second cancer in his study that recruited 1530 subjects 15. Regarding the association between ovarian and breast cancers, it is evidenced by the increased rates of second ovarian cancer after breast cancer in BRCA1/2 mutation carriers 4, 5, 16. As to the patients without BRCA1/2 mutation, the results were inconsistent 10, 14, 15. The gene discussed is BRCA1; the disease is ovarian cancer.