For instance, rs438042, located near the intron/exon boundary of THBS4 exon 3, is associated with Alzheimer Disease and might be important for splicing, since THBS4 acts in inflammatory responses and synaptogenesis (Cagliani et al., 2013; Cocchi et al., 2015). The gene discussed is THBS4; the disease is early-onset autosomal dominant Alzheimer disease.