Theprotein encoded by the FDFT1 gene is the first enzyme incholesterol biosynthesis, and studies have found that this gene can affect bloodlipids, blood sugar, and inflammation, thus participating in obesity-relatedcoronary heart disease, diabetes, and coronary artery calcification (Ding et al., 2015). The gene discussed is FDFT1; the disease is obesity due to melanocortin 4 receptor deficiency.