TheKEGG pathway analysis showed that the 559 differentially expressed genesparticipated in 107 pathways, including the systemic lupus erythematosus pathway,apoptosis, mitogen-activated protein kinase (MAPK) signaling, and insulin signaling.Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiplesystems and multiple organs, and the expression of a variety of autoantibodies. This evidence concerns the gene INS and autoimmune disease.