This study aimed to explore: 1) DNA methylation in the promoter regions of Wilmstumor gene 1 (WT1), NK6 transcription factor related locus 1gene (NKX6-1) and Deleted in bladder cancer 1(DBC1) gene in cervical cancer tissues of Uygur women inXinjiang, and 2) the correlation of gene methylation with the infection ofHPV16/18 viruses. This evidence concerns the gene NKX6-1 and infection.