NFKB1 and Cirrhosis: In cirrhosis, during the hepatic fibrogenic process, MDA may act in three ways: at gene expression levels (regulates gene expression for pro-collagen synthesis), by NF-κB macrophages (transforms Ito cells into myofibroblastic cells for the production of collagen and other components of extracellular matrix), and functions as an antigen in autoimmune response, together with acetaldehyde-protein adducts [29].