Food and Drug Administration approved the use of PSA testing in conjunction withdigital rectal examination (DRE) to screen asymptomatic men for PCa in 1994, the U.S.Preventive Services Task Force (USPSTF) issued a recommendation against PSA-basedscreening in 2012 (Moyer,2012). The gene discussed is KLK3; the disease is posterior cortical atrophy.