CD4 and neoplasm: L19mTNF treatment in combination with melphalan in the WEHI‐164 tumor model reduced Treg cells and induced a long‐lasting T‐cell‐mediated immune response involving CD4+ and CD8+ T cells. As NK cells and DCs could be involved very early in the immune response, TNF from NK cells could play a relevant role in the maintaining the activation status of DCs.