The biological link between the inflamed immune CRC subtype is characterized by marked upregulation of immunosuppressive factors, such as TGF‐β and CXCL12, and high expression of genes encoding chemokines that attract myeloid cells, including chemokine (C–C motif) ligand 2 (CCL2) and the related cytokines IL‐23 and IL‐17, which are known carcino‐genic drivers in colitis‐associated CRC 38. Here, CXCL12 is linked to colorectal carcinoma.