The PDT destruction of primary tumors would generate a pool of tumor‐associated antigens to trigger specific immune responses, which were then amplified by UCNP‐Ce6‐R837‐based PDT as the immune adjuvant, which combined with T‐lymphocyte‐associated protein 4 (CTLA‐4) blockade would effectively induce the generation of TEM‐based immune memory response to prevent tumor relapse, similar to the functions of cancer vaccines. This evidence concerns the gene CTLA4 and neoplasm.