Overall, our data indicate that, in breast tumor‐derived cells with different phenotypes, the sole modulation of Vav1 is sufficient to affect the activation status of Akt1, involved in the insurgence and growth of breast tumors, but not of Akt2, mainly responsible of tumor metastasis (Dillon et al., 2009; Riggio et al., 2017). Here, VAV1 is linked to breast neoplasm.