AKT1 and breast cancer: Abnormal activation of Akt pathways is the most common aberrations of signal transduction in solid tumors, including breast cancer (Mundi et al., 2016; Yang et al., 2016) in which the three known Akt isoforms (Akt1, Akt2, and Akt3) show a phenotype‐related expression (Clark and Toker, 2014; Iacovides et al., 2013).