By investigating in vitro the main events triggered by activated Akt1, we demonstrated that the downmodulation of the p‐Akt1 (Ser473) level induced by Vav1 in MDA‐MB‐231 cells correlates with their reduced proliferation rate, possibly mediated by the Akt/S6K pathway, a well‐described mechanism in breast tumor cells (Riggio et al., 2017). This evidence concerns the gene VAV1 and breast neoplasm.