The malignancy‐associated role of Vav1 has been variously linked to its best known cytoplasmic function as guanosine exchange factor (GEF) for Rho/Rac GTPases (Bustelo, 2002), mainly devoted to the rearrangement of actin cytoskeleton at the basis of the functional changes that characterize tumor cells (Bartolome et al., 2006; Fernandez‐Zapico et al., 2005; Lazer et al., 2009). This evidence concerns the gene VAV1 and neoplasm.