In addition, we revealed that the higher incidence of distant relapses only occurs in patients with p‐Aktlow/Vav1low tumors treated with adjuvant chemotherapy, indicative of the critical role of the balance between expression of Akt and p‐Akt (Ser473) in breast cancer chemo‐resistance and metastasis (Xu et al., 2018). This evidence concerns the gene AKT1 and breast cancer.