AKT1 and neoplasm: Therefore, despite a promising chance, emerging data revealing different or even opposite functional roles of Akt isoforms in the regulation of proliferation, migration, and invasion (Dillon et al., 2009; Li et al., 2016; Riggio et al., 2017) opened the issue of the reliability of the use of pan or isoform‐specific Akt inhibitors in the different tumor subtypes and of the combined use of inhibitors and cytotoxic chemotherapy.