IRAK1 and MALT lymphoma: The DD allows the creation of a multimeric complex, via the oligomerization and interaction with the serine-threonine kinases IRAK1–4, which activate the NF-κB.MYD88 is affected by somatic mutations in 15% of SMZLs and 10% of NMZLs and MALT lymphomas.MYD88 mutations affect a conserved beta-beta loop of the protein TIR domain26,33,59–69 and lead to spontaneous and uncontrolled MYD88/IRAK complex formation59.