The important role of BIRC3-MALT1 fusion protein, as well as MALT1 and BCL10 upregulation, in MALT lymphoma is further underlined by mouse models with development of MALT lymphomas and DLBCL inMALT1 gene transgenic mice57, expansion of marginal zone cells inBIRC3-MALT118,35, and BCL10 transgenic mice58. Here, BCL10 is linked to diffuse large B-cell lymphoma.