By considering the overall AP-F13A1 heterozygous patients (valine/leucine isoform) and homozygous patients (valine/valine or leucine/leucine isoforms), mean of AP-F13A1 were determined to be 181.8 ± 71.0 and 59.4 ± 33.3 ng/mL for control and CRC patients respectively which was significantly different (****P value < 0.0001) (Fig. 3d). Here, DHCR7-DT is linked to colorectal carcinoma.